Adult ≥16 yr 250 mg bid, increase as needed & tolerated in increments of 500 mg bid every 2 wk. Max: 1,500 mg bid.
Childn 4-<16 yr 10 mg/kg bid, increase in increments of 10 mg/kg bid every 2 wk to 30 mg/kg bid;
6 mth-<4 yr 10 mg/kg bid, increase in increments of 10 mg/kg bid every 2 wk to 25 mg/kg bid;
1-<6 mth 7 mg/kg bid, increase in increments of 7 mg/kg bid every 2 wk to 21 mg/kg bid.
Myclonic seizures Adult & childn ≥12 yr 500 mg bid, increase by 500 mg bid every 2 wk to 1,500 mg bid.
Primary generalized tonic-clonic seizures Adult ≥16 yr 500 mg bid, increase by 500 mg bid every 2 wk to 1,500 mg bid.
Childn 6-<16 yr 10 mg/kg bid, increase in increments of 10 mg/kg bid every 2 wk to 30 mg/kg bid.
Adult patient w/ impaired renal function Dose adjustment is recommended based on the patient's estimated CrCl.
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